The former NFL star was acquitted of double murder in the "trial of the century" in 1995, before later being found liable for the deaths. He was then imprisoned for armed robbery and kidnapping.
OJ Simpson, the former American football star and Hollywood actor who was cleared of murdering his ex-wife and her friend in a criminal trial, has died aged 76.
He was surrounded by his children and grandchildren when he "succumbed to his battle with cancer" on Wednesday, his family said on X.
On April 10th, our father, Orenthal James Simpson, succumbed to his battle with cancer.
— O.J. Simpson (@TheRealOJ32) April 11, 2024
He was surrounded by his children and grandchildren.
During this time of transition, his family asks that you please respect their wishes for privacy and grace.
-The Simpson Family
Simpson was tried for double murder in 1995, in what was dubbed the "trial of the century", which gripped the world.
He was found not guilty of killing Nicole Brown Simpson and her friend Ron Goldman, but was later found responsible for the deaths in a civil lawsuit.
Simpson was then imprisoned in 2008 for nine years for armed robbery and kidnapping after an incident at a Las Vegas hotel.
Local 10 News in Nevada reported in February this year that Simpson was undergoing treatment for prostate cancer, but the former NFL running back said in a video at the time that "all is well".
Posting on X, Simpson laughed as he said: "I'm not in any hospice, I don't know who put that out there."
Caitlyn Jenner, whose ex-wife Kris Jenner was a close friend of the retired footballer and Ms Brown Simpson, said bluntly "good riddance" in response to Simpson's death.
David Cook, attorney for Mr Goldman's family, also told TMZ that Simpson "died without penance" as the family is still owed damages. He added that the Goldmans are exploring their options on what assets they can collect from Simpson's estate.
Simpson was acquitted after a 1995 criminal trial watched by millions worldwide, where Simpson famously tried on a pair of blood-stained gloves allegedly found at the scene of the crime.
The gloves appeared to be too small, leading defence attorney Johnnie Cochran to say: "If it doesn't fit, you must acquit."
Alan Dershowitz, another of Simpson's lawyers at the time, said the defence was "a nightmare team" and that he did not want the former NFL star to take the stand.
"Ultimately it was the glove" that persuaded Simpson not to speak at the trial, Mr Dershowitz told Sky News.
"When he was able to go in front of the jury and show them that the glove didn't fit, that led him to conclude, and he made the decision, not to take the stand.
"In the civil case, he took the stand and was immediately found liable."
Nicknamed "The Juice", Orenthal James Simpson rose to fame as a sports star in the Buffalo Bills team.
He was enrolled in the NFL's hall of fame and was the first running back to gain 2,000 yards in a season in 1973.
He also became known as an advertising star, football commentator and Hollywood actor, appearing in a number of TV and film roles including the Naked Gun movie series.
Simpson was charged with two counts of first-degree murder after Ms Brown Simpson and Mr Goldman were stabbed to death at her Los Angeles home on 12 June 1994.
After he was accused of the killings, Simpson wrote a letter which insisted he was innocent, said goodbye to friends and made "a last wish" to "leave my children in peace".
On 17 June that year, his lawyer Robert Shapiro feared Simpson was suicidal, while a white Ford Bronco carrying the former footballer led police on a 60-mile chase through Los Angeles.
Simpson was acquitted of double murder on 3 October 1995.
A civil wrongful death lawsuit later found him liable for the two deaths in 1997. He was ordered to pay $33.5m in damages, but he declared bankruptcy shortly after.
Simpson was later arrested in 2007 for armed robbery and kidnapping in a dispute over sports memorabilia at a Las Vegas casino hotel.
He was sentenced to up to 33 years in prison in 2008. After nine years in a Nevada prison, he was released on parole in 2017 and then discharged from parole for good behaviour in 2021.
Since then, Simpson regularly commented on politics and sports on social media. He lived in a gated community in Las Vegas where he played golf.