Police are investigating a collision on the A24 between Findon and Washington.
Emergency services were called to the incident at about 8.45am on Thursday, November 16.
The dual carriageway was closed in both directions while emergency services responded to the incident.
The collision involved three vehicles, and a man was airlifted to the Royal Sussex Country Hospital via Air Ambulance with serious injuries.
Officers have appealed for witnesses or anyone with relevant CCTV or dashcam footage of the collision or vehicles in the area at the time to come forward.
Motorists are advised that there may be delays in the area while the incident is responded to, but the road is expected to reopen in the early afternoon.
Information can be reported to Sussex Police online or via emailing: [email protected] and quoting serial 247 of 16/11.